Linda S. Gutierrez
Assistant Professor of Biology
1980-1987 MD Universidad de Carabobo, Venezuela
1990-1993 Anatomic-Pathology Specialist Universidad Central de Venezuela
1994-1998 Post-doctoral Fellow Yale University
Inflammatory bowel disease; colorectal, breast and prostate cancers; angiogenesis; apoptosis
Current research projects:
More than 1.4 million Americans suffer from inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. Patients with IBD have a high risk of developing colorectal cancer. These chronic and idiopathic diseases seriously affect the quality of life of the patients and represent a significant burden on the country’s health care system.
Dr. Gutierrez is investigating the role of thrombospondin 1 (TSP-1) in the development of these diseases and testing specific sequences of this protein as a novel and safe therapy for IBD and colorectal cancer. Thrombospondin 1 (TSP-1) is a powerful antiangiogenic with diverse roles in physiological and pathological events. This 450Kd glycoprotein interacts with members of different pathways regulating cell migration, proliferation and apoptosis. These are the on-going projects currently expanded by NIH support:
Honors, Awards and Nominations:
1984 Undergraduate Intern Award, (IPG), University of Carabobo, Venezuela.
1985 Undergraduate Intern Award, (IPG), University of Carabobo, Venezuela.
1986 Honor and Merit mention, Gynecology and Obstetrics Undergraduate, University of Carabobo.
1990 Ministry of Health and Social Security Scholarship, Universidad Central de Venezuela.
2002 Investigator Supplement Award, NIH/NHLBI
2004 FASEB Summer Conference Travel Award
2005 Abbott Pre-clinical Investigator Collaboration Award
2005 Adjunct Faculty Teaching Award, Wilkes University
2005 Innovative Teaching Award nomination, Wilkes University
2006 Saidman Chair in Health Sciences, Wilkes University
2006 Steps To A Healthier PA Luzerne County, Merit Community Team