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Faculty and Staff

Contact

Office: Stark Learning Center

Phone: 5704084336

Email: adam.vanwert@wilkes.edu

Dr. Adam L. VanWert

Associate Professor

Pharmaceutical Sciences

Biography

Dr. VanWert returned to Wilkes in the fall of 2008 after receiving his Ph.D. from the Medical University of South Carolina (MUSC).  His doctoral research was in the area of drug transport in the kidney.  His didactic training was broad, with a focus on toxicology.  His current research involves investigation of the interactions between antibiotics and kidney transporter proteins (e.g., OAT3).  Techniques used include HPLC, Western blotting, and cell culture.  He works with students in the lab during both the school year and summer; the latter being supported by a Wilkes Mentoring Grant.  He was introduced to research at Wilkes while working with Dr. James Culhane from 2000-2003.  He was offered jobs in both the FDA and biotech sectors, but chose to return to Wilkes because of his passion for teaching, his positive experience with the faculty, and the family-like environment on campus.

 
On the teaching front, Dr. VanWert has been recognized as Teacher of the Year (2009-2010).  He teaches pharmacology of several disease states, e.g., cardiovascular, neoplastic, and gastrointestinal.  He has also developed a toxicology elective in which guest lecturer, Jeanna Marraffa, Pharm.D., DABAT (Upstate Medical University Poison Center, SUNY), introduces clinical toxicology to pharmacy students.
 
Most recently, Adam has been invited to become a Graduate Affiliate Faculty member in the Pharmaceutics Department at Virginia Commonwealth University (VCU).  He will serve on dissertation committees in this role.  In addition, he was invited to present his research at VCU in the Pharmaceutics Seminar Series on October 23, 2012.
 

Publications

Peer-Reviewed Original Research Manuscripts and Review Articles

  • Witczak ZJ, Poplawski T, Czubatka A, Sarnik J, Tokarz P, VanWert AL, Bielski R. A potential CARB-pharmacophore for antineoplastic activity: Part 1. Bioorg Med Chem Lett 24: 1752-1757, 2014.
     
  • Bommareddy A, Eggleston W, Prelewicz S, Antal A, Witczak ZJ, McCune DF and VanWert AL. Chemoprevention of Prostate Cancer by Major Dietary Phytochemicals. Anticancer Research 33: 4163-4174, 2013.
     
  • Wolman AT, Gionfriddo MR, Heindel GA, Mukhija P, Witkowski S, Bommareddy A, VanWert AL. Organic anion transporter (OAT3) interacts selectively with lipophilic β-Lactam antibiotics. Drug Metabolism and Disposition, 41(4):791-800, 2013.
     
  • Bommareddy A, Rule B, VanWert AL et al. Alpha-santalol, a chemopreventive agent induces apoptosis in human prostate cancer cells by causing caspase-3 activation. Phytomedicine Journal 19(8-9): 804-11, 2012.
  • VanWert AL, Gionfriddo MR, Sweet DH. Organic Anion Transporters: Discovery, Pharmacology, Regulation, and Roles in Pathophysiology. Biopharm Drug Disp 31: 1-71, 2010.
     
  • VanWert AL, Srimaroeng C,and Sweet DH. Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin.Mol Pharmacol 74(1):122-131, 2008.
     
  • VanWert AL and Sweet DH. Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates. Pharm Res 25(2): 453-462, 2008.
     
  • VanWert AL, Bailey RM, and Sweet DH. Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G. Am J Physiol Renal Physiol 293: F1332-1341, 2007.
     
  • Patrick KS, Williard RL, VanWert AL et al. Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol. J Med Chem 48: 2876-2881, 2005.
     
  • Gupta MK, VanWert A, and Bogner RH. Formation of physically stable amorphous drugs by milling with Neusilin. J Pharm Sci 92: 536-551, 2003.


Scientific Cell Phone Applications Published on the Android Market (free)

  • VanWert AL. “Best Serial Dilution Calc”. Available on Google Play Dec, 2012 (2,945 downloads internationally as of March 26, 2014). Multilingual interface (Japanese, Chinese, Russian, Italian, Spanish, French, and other languages available).

 
Abstracts
  • Brown KM, Aungst TD, Castro C, Bommareddy A, VanWert A, McCune DF. Alpha1-adrenergic receptor subtype specific activation of ERK in human primary smooth muscle cells. Experimental Biology annual meeting, Abstract tracking number 14-3901-EB, April 29, 2014.
     
  • Kibbe A, VanWert A, Mencer D, Zawistowski K. Diffusional Analysis of Topical Gel Formulations. AAPS J, Abstract ID (accepted June 2013).
     
  • Wolman A, Bommareddy A, Gionfriddo M, Witkowski S, Heindel G, Mukhija P, VanWert A. Organic Anion Transporter 3 (Oat3) Interacts Selectively with Lipophilic β-Lactam Antibiotics. AAPS J, Abstract ID AM-13-0426 (accepted June 2013).
     
  • Bommareddy A, Eggelston W, Prelewicz S, Antal A, VanWert A, et al. Chemoprevention of prostate carcinogenesis in TRAMP mice by α-santalol by causing cell cycle arrest and induction of apoptosis. 104th annual AACR conference, Washinton, D.C. April 2013.
     
  • Bommareddy A, Rule B, VanWert A, et al. Alpha-santalol, a chemopreventive agent induces apoptosis in human prostate cancer cells by causing caspase-3 activation. 103rd annual AACR conference, Chicago, IL. April 2012.
     
  • Kibbe A, VanWert A, Jacobs H, et al. Lisinopril as a liquid dosage form intended for pediatric use. AAPS J 13(S2), 2011.
     
  • Beidel B, Bohan J, D’Ippolito C, Thudium E, VanWert A, Jacobs H, Kibbe AH. Liquid dosage forms intended for pediatric use: Lisinopril & Meclizine. AAPS J 13(S2), 2011.
     
  • VanWert AL and Gionfriddo MR. Novel Interactions of β-Lactam Antibiotics with Renal Organic Anion Transporter 3 (Oat3). AJPE 74(5): Article 96, 2010.
     
  • VanWert AL et al. Achieving the Scholarship of Assessment, Learning, and Teaching (SALT) through Strategic Planning. AJPE 74(5): Article 96, 2010.
     
  • VanWert AL and Sweet DH. Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates. AAPS J 9(S2), abstract 704, 2007.
     
  • VanWert AL and Sweet DH. Altered in vivo drug disposition in organic anion transporter 3 knockout mice. AAPS J 8(S2), abstract 1291, 2006.
     
  • VanWert AL and Sweet DH. Organic anion transporter (OAT) expression and function in primary murine renal proximal tubule cell cultures. FASEB J 19(4): A157, 2005.
     
  • Culhane JM, Cavage J, VanWert A.  Analysis of nifedipine sensitivity in primary, secondary and tertiary branches of the superior mesenteric arterial vascular bed from dahl-salt sensitive and dahl-salt resistant rats. FASEB J, 2004.
     
  • Culhane JM, Cavage J, VanWert A.  Alterations in vascular nifedipine sensitivity during the development of salt-sensitive hypertension. FASEB J 17: A645, 2003.
     
  • Culhane JM, Cavage J, VanWert A. Nifedipine sensitivity in mesenteric arterial vasculature from dahl rats. FASEB J 15: A214, 2001.

Presentations
  • Poster Presentation, “Organic Anion Transporter 3 (Oat3) Interacts Selectively with Lipophilic β-Lactam Antibiotics”, annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, TX, November 10-14, 2013.
     
  • Invited research seminar, Virginia Commonwealth University (VCU), Department of Pharmaceutics, “Exploiting β-Lactam Diversity to Investigate Physicochemical Determinants of Drug-Organic Anion Transporter Interactions”, October 23, 2012.
     
  • Research presentation, Faculty Forum hosted by the Provost, Wilkes University, “Current Research: Organic Anion Transporters (OATs)”, September 16, 2011.
     
  • Research presentation, Nesbitt College of Pharmacy and Nursing, Wilkes University, “Current Research in Organic Anion Transporters (OATs)”, January 27, 2011.
     
  • Poster Presentation, “Novel Interactions of β-Lactam Antibiotics with Renal Organic Anion Transporter 3 (Oat3)”, annual meeting of the American Association of Colleges of Pharmacy (AACP), Seattle, WA, 2010.
     
  • Poster Presentation, “Achieving the Scholarship of Assessment, Learning, and Teaching (SALT) through Strategic Planning”, annual meeting of the American Association of Colleges of Pharmacy (AACP), Seattle, WA, 2010.
     
  • Poster presentation, “Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates”, annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Diego, CA, 2007.
     
  • Podium and poster, “Altered in vivo substrate disposition in organic anion transporter 3 knockout mice”, annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, TX, 2006.
     
  • Poster presentation, “Organic anion transporter (OAT) expression and function in primary murine renal proximal tubule cell cultures”, 35th International Congress of Physiological Sciences
    /annual meeting of the Federation of American Societies for Experimental Biology,
    San Diego, CA, 2005.
     
  • In-service presentation to physicians, “Herbal drug therapy”, pharmacy clerkship, Nesbitt Hospital, Kingston, PA, 2003.
     
  • Poster presentation, “Formation of physically stable amorphous drugs by milling with Neusilin”, 23rd Annual Pharmacy Student Research Conference – Eastern States, West Virginia University, Morgantown, WV, 2001.
 

Research

Dr. VanWert’s research deals primarily with characterizing drug transporters in the body.  During his graduate training he was interested in determining the role of organic anion transporter 3 (Oat3) in the disposition of a variety of drugs.  A major finding from this work was the discovery that Oat3 is a critical protein involved in the renal elimination of benzylpenicillin (penicillin G), as well as other commonly used drugs.  With knowledge gained on this transporter, and an arsenal of techniques to assess transporter function and expression, he has formulated several new research questions.  One major goal is to evaluate the potential for quantitative structure-activity relationship (QSAR) analysis in the development predictive models; particularly models that can predict drug-drug transporter affinity/activity based on physicochemical properties of the drug.  This pursuit will ideally lead to more opportunities for rational drug design, and thus, more expeditious development of efficacious drugs.  Techniques that students are actively learning and employing in his lab include HPLC, fluorescence spectroscopy, drug transporter assays, mammalian cell culture, immunoblotting, and others.  He welcomes new opportunities for collaboration, and encourages interested readers to contact him at adam.vanwert@wilkes.edu.

Adam and several students have recently published an original research article in Drug Metabolism and Disposition. Their findings revealed important information about drug recognition by Oat3.

Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics

 

 

Awards

  • Elected Teacher of the Year in the School of Pharmacy (Wilkes University)
    Elected by P-2 pharmacy students (4th year of college) to be the P-2 Teacher of the Year
    2009-2010
     
  • Travel Award to AAPS Workshop (MUSC)
    American Association of Pharmaceutical Scientists Workshop on Enzyme- and Transporter-Based Drug Interactions, San Diego, CA.
    2007
     
  • AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences (MUSC)
    American Foundation for Pharmaceutical Education fellowship won in national competition.
    Awarded supply and travel funds; successfully renewed ($6000/year).
    2005-2006
     
  • Awarded Ph.D. Candidate Status (MUSC)
    Successfully proposed and defended research plan.
    2006
     
  • Chancellor's List (MUSC)
    Academic honor for graduate students.
    2005-2006
     
  • GAANN Fellowship (MUSC)
    U.S. Department of Education “Graduate Assistance in Areas of National Need” fellowship. Awarded a stipend and supply/travel funds (~$25,000), and provided teaching experience at the Citadel Military College.
    2003-2004
     
  • Certificate of Achievement in Pharmacy (TEVA Pharmaceuticals) (Wilkes U.)
    Chosen based on academic performance.
    2003
     
  • Rho Chi Honor Society in Pharmacy (Wilkes U.)
    Inducted based on academic performance and elected chapter historian.
    2002
     
  • National Dean's List (Wilkes U.)
    Inducted based on academic performance.
    2001-2003
     
  • Phi Eta Sigma Freshman Honor Society (Wilkes U.)
    Inducted based on academic performance.
    1998

Images

In Dr. VanWert’s Toxicology elective students have the opportunity to engage the community. For one course project several students and faculty educated senior citizens on poison prevention at the annual Senior Expo at the Kingston Armory, Kingston, PA. One focal point addressed by the students was the prevention of carbon monoxide poisoning in the home, an unfortunate threat that surfaces particularly during inclement weather. The group was very excited to meet Senators John Yudichak and Lisa Baker (below).

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