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Faculty and Staff

Contact

Office: Stark Learning Center

Phone: 5704084220

Email: ajay.bommareddy@wilkes.edu

Dr. Ajay Bommareddy

Assistant Professor

Pharmaceutical Sciences

Biography

Dr. Bommareddy joined the department in the fall of 2009 after completing a two year postdoctoral research work at the University Of Pittsburgh School Of Medicine, Department of Pharmacology & Chemical Biology in the area of cancer chemoprevention using naturally occurring phytochemicals.  He received his Ph.D in 2007 from South Dakota State University with a specialization in pharmaceutical Sciences where his dissertation focused on investigating “chemoprevntive properties of dietary flaxseed meal on colon tumor development” using cell culture and animal models. 

In the department, Dr. Bommareddy maintains an active research profile in the areas of prostate and breast cancer chemoprevention using naturally occurring phytochemicals. On the teaching front, he teaches introductory anatomy & physiology (PHA 331/332) course in the spring semester to P-1 class and also pharmacology of various disease states, e.g., endocrine (PHA 526), neoplastic (PHA528), and renal (PHA 525) to P-3 class.  He has also developed an elective on phytochemicals and their role on health & disease (PHA 556). 

Publications

Peer-Reviewed Original Research Manuscripts and Review Articles (relevant to cancer chemoprevention research – since 2009)

  • Bommareddy A, Eggleston W, Prelewicz S, Antal A, Witczak Z, McCune DF, VanWert AL. Chemoprevention of prostate cancer by major dietary phytochemicals. Anticancer Research, 33: 4163-4174, 2013.
     
  • Santha S, Bommareddy A, Rule B, Guillermo R, Kaushik RS, Young A, Dwivedi C. Antineoplastic effects of α-santalol on estrogen receptor-positive and estrogen receptor- negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis. PLoS ONE 8(2): e56982. 2013
     
  • Bommareddy A, Rule B, VanWert AL, Santha S and Dwivedi C. Alpha-santalol, a chemopreventive agent induces apoptosis in human prostate cancer cells by causing caspase-3 activation. Phytomedicene, 19: 804-811, 2012.
     
  • Xiao D, Bommareddy A, Kim S-H, Sehrawat A, Hahm E-R, et al. (2012) Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells. PLoS ONE 7(3): e32597. 2012.
     
  • Kim SH, Bommareddy A, and Singh SV. Garlic Constituent Diallyl Trisulfide Suppresses X-Linked Inhibitor of Apoptosis Protein in Prostate Cancer Cells in Culture and In Vivo. Cancer Prevention Research (Phila), Jun;4(6):897-906, 2011.
     
  • Powolny AA, Bommareddy A, Hahm ER, Normolle DP, Beumer JH, Nelson JB, Singh SV. Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostate Cancer. JNCI, 103(7):571-584, 2011.
     
  • Bhatia E, Doddivenaka C, Zhang X, Bommareddy A, Krishnan P, Matthees DP and Dwivedi C. Chemopreventive Effects of Dietary Canola Oil on Colon Cancer Development. Nutrition & Cancer, 63 (2): 242-247, 2011.
     
  • Bommareddy A, Zhang X, Kaushik R and Dwivedi C. Effects of components present in flaxseed on human colon adenocarcinoma CACO-2 cells, possible mechanisms of action of flaxseed on colon cancer development .Drug Discoveries & Therapeutics 4(3): 184-189, 2010.
     
  • Warin R, Xiao D, Arlotti JA, Bommareddy A and Singh SV. Inhibition of human Breast cancer xenograft growth by cruciferous vegetable constituent Benzyl Isothiocyanate. Molecular Carcinogenesis 49 (5): 500-7, 2010.
     
  • Xiao D, Powolny AA, Barbi de Moura M, Kelley EE, Bommareddy A, Kim SH, Hahm ER, Normolle D, Van Houten B, Singh SV. Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J Biol Chem, 285(34):26558-69, 2010.
     
  • Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher A, Jiang Y, and Singh SV.ATG5 Regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Research 69(8): 3704-12, 2009.
     
  • Bommareddy A, Zhang X, Schrader D, Kaushik R, Zeman D, Mathees DP and Dwivedi C. Effects of dietary flaxseed on Intestinal tumorigenesis in ApcMin mice Nutrition and cancer, 61(2): 276-283, 2009.
     
  • Xiao D, Antosiewicz J, Hahm E , Powolny A, Bommareddy A, Zeng Y, Desai D, Amin S, Herman-Antosiewicz A and Singh SV. Cellular responses to dietary cancer chemopreventive agent D, L-sulforaphane in human prostate cancer cells are initiated by mitochondria-derived reactive oxygen species. Pharmaceutical Research, 26(7):1729-38, 2009.
     
  • Singh SV, Warin R, Xiao D,Powolny A, Stan SD, Arlotti JA, Zeng Y, Hahm E, Marynowski SW, Bommareddy A, Desai D, Amin S, and Chambers WH. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Research, 69(5):2117–25, 2009.


Abstracts & poster presentations
(relevant to cancer chemoprevention research – since 2009)

  • Ajay Bommareddy, Lauren Lockus, Jonathan Seward, William Eggelston, Stacy Prelewicz, Andrea Antal, Sarah Fillman, Christian Casto, Adam L. Van Wert, Sreevidhya Santha and Chnadradhar Dwivedi. Akt/Survivin pathway inhibition synergizes apoptotic cell death induced by α-santalol in prostate cancer cells. 105th annual AACR conference, Sandiego (April 7th 2014).'
     
  • Ajay Bommareddy, William Eggelston, Stacy Prelewicz, Andrea Antal, Adam L. Van Wert, Hiral Patel, Aleona Chinikaylo, Linda S. Gutierrez, Sreevidya Santha and Chandradhar Dwivedi. Chemoprevention of prostate carcinogenesis in TRAMP mice by α-santalol by causing cell cycle arrest and induction of apoptosis. 104th annual AACR conference, Washington, D.C (April 9th 2013).
     
  • Ajay Bommareddy, Brittny Rule, Adam L. VanWert, Sreevidya Santha, Chandradhar Dwivedi. Alpha-santalol, a chemopreventive agent induces apoptosis in human prostate cancer cells by causing caspase-3 activation. 103rd annual AACR conference, Chicago, IL (April 2012).

  • Sreevidya Santha, Ajay Bommareddy, Brittny Rule, Ruth Guillermo, Radhey S. Kaushik, Alan Young, Chandradhar Dwivedi. α-santalol induces caspase-dependent apoptosis and G2/M phase cell cycle arrest in human breast cancer cells. 103rd annual AACR conference, Chicago, IL (April 2012)
     
  • Ajay Bommareddy, Brittny Rule, Bethany Sharpless, Lauren Machell, Lindsey Coval, Sreevidya Santha, Chandradhar Dwivedi. Anticancer effects of alpha-santalol on prostate cancer development. Annual AACP conference, San Antonio, TX (July 2011).
     
  • Ajay Bommareddy, Su-Hyeong Kim and Shivendra V. Singh. Garlic Constituent Diallyl Trisulfide Suppresses X-Linked Inhibitor of Apoptosis Protein in Prostate Cancer Cells in Culture and In Vivo. 102nd annual AACR conference, Orlando, FL (April 2011).
     
  • Dong Xiao, Ajay Bommareddy andShivendra V. Singh. Benzyl isothiocyante causes FOXO1-mediated autophagic death in cultured and human breast cancer cells. 102nd annual AACR conference, Orlando, FL (April 2011).
     
  • Anna A. Powolny, Ajay Bommareddy, Eun-Ryeong Hahm, Daniel P Normolle, Jane H Beumer, Joel B Nelson, Shivendra V Singh. Phenethyl isothiocyanate-mediated inhibition of prostate cancer development in TRAMP mice is associated with induction of autophagy and suppression of plasma clusterin. 102nd annual AACR conference, Orlando, FL (April 2011).
     
  • Ajay Bommareddy, Renaud Warin, Dong Xiao, Julie A. Arlotti, Shivendra V. Singh. Benzyl isothiocyanate-mediated growth inhibition of MDA-MB-231 human breast cancer xenograft is associated with reduced cell proliferation, inhibition of angiogenesis, and induction of autophagy. 101st annual AACR conference, Washington D.C (April 2010).
  • Anna A. Powolny, Dong Xiao, Michelle Barbi de Moura, Ajay Bommareddy, Eun-Ryeong Hahm, Bennett Van Houten, Shivendra V. Singh. Phenethyl isothiocyanate inhibits oxidative phosphorylation to initiate reactive oxygen species-mediated death of human prostate cancer cells. 101st annual AACR conference, Washington D.C (April 2010).

  • Ajay Bommareddy, Hahm ER, Xiao D, Powolny AA, Fisher A, Jiang Y, and Singh SV.ATG5 Regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. 21st Annual University of Pittsburgh Cancer Institute Scientific Retreat, Greensburg, PA (June 2009).

  • Eun-Ryeong Hahm, Dong Xiao, Jedrzej Antosiewicz, Anna A. Powolny, Ajay Bommareddy, Yan Zeng, Shivendra V. Singh. Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by the mitochondria-derived reactive oxygen species. 100th annual AACR conference, Denver, CO (April 2009).

  • Anna A. Powolny, Renaud Warin, Dong Xiao, Silvia D. Stan, Julie A. Arlotti, Yan Zeng, Eun-Ryeong Hahm, Stanley W. Marynowski, Ajay Bommareddy, Dhimant Desai, Shantu Amin, William H. Chambers, Shivendra V. Singh. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with reduced cell proliferation and increased apoptosis. 100th annual AACR conference, Denver, CO (April 2009).

  • Shivendra V. Singh, Anna A. Powolny, Silvia D. Stan, Dong Xiao, Julie A. Arlotti, Renaud Warin, Eun-Ryeong Hahm, Stanley W. Marynowski, Ajay Bommareddy  Douglas M. Potter, Rajiv Dhir. Oral administration of diallyl trisulfide inhibits development of poorly-differentiated prostate cancer and pulmonary metastasis in TRAMP mice. 100th annual AACR conference, Denver, CO (April 2009).

  • Renaud Warin, William H. Chambers, Douglas M. Potter, Julie A. Arlotti, Ajay Bommareddy, Kenneth S. McCarty, Shivendra V. Singh. Dietary administration of benzyl isothiocyanate inhibits mammary hyperplasia/carcinoma incidence and/or burden in MMTV-neu mice. 100th annual AACR conference, Denver, CO (April 2009).


Invited Oral Presentations

  • Chemopreventive effects of α-santalol, a component of sandalwood oil on Prostate Cancer Development. Becton College school of Pharmacy, Fairleigh Dickinson University, Madison, NJ (January 6th 2014).

  • Chemoprevention of prostate cancer by naturally occurring phytochemicals. Wilkes University Faculty Forum presentation, Wilkes University, Wilkes-Barre, PA (March 16th 2012).

  • Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. 27th annual retreat, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA (July 24th, 2009).

  • Chemopreventive effects of Phenethyl Isothiocyanate on prostate cancer development. Nesbitt College of Pharmacy, Wilkes University, Wilkes-Barre, PA (June 4th, 2009).

  • Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. 100th annual AACR conference, Denver, CO (April 21st 2009).

  • Chemopreventive effects of dietary flaxseed on colon tumor development. Sigma Xi research paper competition, South Dakota State University, Brookings, SD (April, 2006).
 

Book chapters
  • Anna A Powolny, Ajay Bommareddy, Shivendra V. Singh. Slow but Steady Progress in Cancer Chemoprevention with Phenethyl Isothiocyanate: Fulfilled Promises and Translational Challenges. Springer Link; Nutraceuticals and Cancer: Chapter 12, 231-258, 2012.

Research

The long-term goal of my research is to identify the mechanism (s) through which the naturally occurring active compounds inhibit the cancer growth & development, and contribute substantially to enhance our understanding of the disease prevention and treatment.

About chemoprevention

Cancer chemoprevention is a strategic approach of using natural, synthetic agents to reverse, suppress, or prevent the development of cancer. Natural products have attracted increasing attention in recent years, not only for identification of active constituents for cell biological applications as molecular probes of protein functions, but also for the discovery of novel cancer chemopreventive/therapeutic agents. Cancer occurs when cells within a particular organ/tissue or glands grow uncontrollably, creating small tumors.  Cancer at its primary stage, if diagnosed is often curable (rates of 90% or better) with standard interventions such as radiation therapy and surgery that aim to remove or kill all cancerous cells.  Unfortunately, at this early stage this deadly malignancy produces few or no symptoms and can be difficult to detect. If untreated and allowed to grow, the cells from these tumors can spread to other parts of the body in a process called metastasis.  In this process, cancer cells are transported through the lymphatic system and the bloodstream to other parts of the body, where they lodge and grow secondary tumors.  Once the cancer has spread beyond the organ of origin, treatment options are very minimal and cure rates drop dramatically. Chemoprevention by natural agents/synthetic compounds is typically used by people who have a higher risk of developing cancer, including those with a previous cancer, an inherited cancer syndrome, or a family history of cancer.

 

 

Awards

  • Nominated for “outstanding new faculty award”, Nesbitt School of Pharmacy, Wilkes University, Wilkes-Barre, PA – 2012
     
  • American Association of Colleges of Pharmacy (AACP) New Faculty Research Award, $ 10,000: Awarded by AACP – 2010-2011
     
  • Travel grant, $ 1,000 awarded by AACP – 2011
     
  • University of Pittsburgh Cancer Institute Director’s award for scientific excellence: First place in Translational & Clinical research section, poster presentation at 21st Annual University of Pittsburgh Cancer institute Retreat, Greensburg, PA – 2009
  • University first place for sigma xi Ph.D paper presentation contest, South Dakota State University Sigma Xi Chapter, Brookings, SD – 2007

  • Rho Chi Honor Society in Pharmacy, South Dakota State University - 2006: Inducted based on academic performance.

  • Awarded “Zora Colburn Scholarship” for Academic excellence, $2,000: Department of Nutrition & Food Sciences, College of Family & Consumer Sciences, South Dakota State University, Brookings SD – 2003

 

Images

Students with Dr. Bommareddy at the annual AACR conference (2013) held in Washington D.C.

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