Dr. William J. Biggers
- Cohen Science Center, 208
- (570) 408-3375
MWPS 1983 Wood and Paper Science, with minor in Toxicology, North Carolina State University
BS 1980 Biochemistry, North Carolina State University
Larval settlement and metamorphosis
Invertebrate reproduction and development
Comparative physiology and biochemistry
Current research projects
Effects of serotonin on settlement and metamorphosis of the polychaete annelid Capitella teleta
Influence of algae and bacteria on induction of settlement and metamorphosis of Capitella teleta larvae
Investigation into the effect of 2,4-decadienal on growth and reproduction of Capitella teleta.
Marine diatoms are known to produce toxic aldehydes which adversely affect the reproduction and development of several marine invertebrates. We are now carrying out experiments to determine the effect of one of these aldehydes, 2,4-decadienal, on growth and reproduction of Capitella.
Assessment of Oxidative Stress in Passerine Birds
In collaboration with Dr. Jeff Stratford, we have begun to assess levels of oxidative stress in several species of passerine birds by measuring levels of the oxidative stress associated enzymes glutathione-s-transferase and glutathione peroxidase as part of a project which has received funding from the Pennsylvania Department of Conservation and Natural Resources (DCNR).
We are hoping to correlate levels of oxidative stress with exposure to environmental
contaminants encountered in different habitats.
Biggers, W.J., A. Pires, J.A. Pechenik, E. Johns, P. Patel, T. Polson, and J. Polson. 2012.
Inhibitors of Nitric Oxide Synthase Induce Larval Settlement and Metamorphosis of the
Polychaete Annelid Capitella teleta. Invertebrate Reproduction and Development 56:1-13.
Laufer, H., X. Pan, W.J. Biggers, C.P. Capulong, J.D. Stuart, N. Demir, and U. Koehn. 2005.
Lessons learned from inshore and deep-sea lobsters concerning alkylphenols. Invertebrate
Reproduction and Development 48: 109-117.
Laufer, H., N. Demir, and W.J. Biggers. 2005. The lobster's response to the effects of shell
disease. Journal of Shellfish Research 24: 757-760.
Biggers, W.J. and H. Laufer. 2004. Identification of juvenile hormone-active alkylphenols in the
lobster Homarus americanus and in marine sediments. Biological Bulletin 206: 13-24.
Laufer, H. and W.J. Biggers. 2001. Unifying Concepts Learned from Methyl Farnesoate for
Invertebrate Reproduction and Post-Embryonic Development. Amer. Zool. 41: 442-457.
by juvenile hormone-active compounds is mediated by protein kinase C and ion channels.
Biological Bulletin 196: 187-198.
Biggers, W.J. and H. Laufer. 1996. Detection of juvenile hormone-active compounds by
Biggers, W.J. and H. Laufer. 1992. Chemical induction of settlement and metamorphosis of
Capitella capitata sp. I (Polychaeta) larvae by juvenile hormone-active compounds.
Invert. Reprod. Dev. 22: 39-46.
Laufer, H. and W.J. Biggers. 1992. Juvenile hormone-like compounds in Crustacea and their
implications for receptor evolution. In: Recent Advances in Cellular and Molecular
Biology, Vol. 4, R. Wegmann and M. Wegmann, Eds., Peeters Press, Leuven, Belgium,